Can Back Pain Be a Symptom of Axial Spondyloarthritis (AxSpA)? (2023)

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(Video) Unexplained Back Pain Could Be Axial Spondyloarthritis (axSpA)
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  • Can Back Pain Be a Symptom of Axial Spondyloarthritis (AxSpA)? (3)



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s=o._config.panel;o._panelParentNode=document.querySelector(s.parentSelector),o._badgeNode=o._config.badge.selector&&document.querySelector(o._config.badge.selector),o._indicatorNode=s.indicatorSelector&&document.querySelector(s.indicatorSelector)}return createClass(e,[{key:"createPanelParentNode",value:function(){this._view.createPanelParentNode(this._panelParentNode),this._notifPanelNode=document.getElementById(constants.panelNodeId)}},{key:"refreshPanelNode",value:function(e,n){var t=this;addClass(t._notifPanelNode,constants.panelLoading),t._store.fetchNotifications(e,(function(e,i){var o=window.wafer&&window.wafer.base;o&&o.destroy(t._notifPanelNode),e?t._notifPanelNode.innerHTML||(t._view.render(ERROR_PANEL$1),addClass(t._notifPanelNode,constants.panelLoading)):(t._view.render(EXPANDED_PANEL$1),t._view.updateBadgeNode(t._badgeNode),t._showBadge(),t._showIndicator(),t._view.addStyles(i.css)),removeClass(t._notifPanelNode,constants.panelLoading),o&&o.sync(t._notifPanelNode.parentNode),n&&n(e,i)}))}},{key:"resetBadge",value:function(){var e=this;e._store.resetNewCount(),e._view.updateBadgeNode(e._badgeNode),addClass(e._badgeNode,e._config.badge.hideClass)}},{key:"_showIndicator",value:function(){this._indicatorNode&&(this._store.getNotifications().newCount?addClass(this._indicatorNode,this._config.panel.indicatorClass):removeClass(this._indicatorNode,this._config.panel.indicatorClass))}},{key:"_showBadge",value:function(){var e=this;e._store.getNotifications().newCount?removeClass(e._badgeNode,e._config.badge.hideClass):addClass(e._badgeNode,e._config.badge.hideClass)}}]),e}(),config={promos:{eligibleBodyClass:"display-push-promos",enableNotifOnboard:!0,bypassEligibleClassCheck:!1,notifOnboardBtnLabel:"Notify Me",notifOnboardMsg:"Get alerts for breaking news and top stories",promoLogo:"",showYahooLogo:!0,subscriptionTopic:"gondor_homerun_news"},badge:{hideClass:"",maxCount:5,selector:""},panel:{emptyPanelMsg:"You have no new notifications.",errorMsg:"",headerMsg:"Notifications",imageTag:"img:40x40|2|80",indicatorClass:"yns-indicator",indicatorSelector:null,maxCount:6,notificationCenterNavMsg:"View all {newCount} notifications",notificationCenterPath:"",notificationTypes:"",parentSelector:null,styleTagId:"notificationStyles",theme:"default"},service:{attemptCount:1,attemptDelay:2,url:null,resetUrl:null,isRMP:!1,responseType:"json",timeout:1500}},Main=function(){function e(n){classCallCheck(this,e);var t=this;t.config=t._parseConfig(n),t._validateRequiredConfigs()&&(t._request=new NotificationRequest(t.config),t._store=new NotificationStore(t.config,t._request),t._view=new NotificationView(t.config,t._store),t._panelController=new PanelController(t.config,t._store,t._view),t._panelController.createPanelParentNode(),t._assignHelperMethods())}return createClass(e,[{key:"_parseConfig",value:function(e){var n={};for(var t in objectAssign(n,config),n)if(n.hasOwnProperty(t)){var i=n[t],o=e[t];"object"===(void 0===i?"undefined":_typeof(i))?objectAssign(i,o):n[t]=e[t]}return n}},{key:"_validateRequiredConfigs",value:function(){var e=this.config;return!(!e.panel.parentSelector||!e.service.url)}},{key:"_assignHelperMethods",value:function(){var e=this;e.helpers={refreshPanelNode:e._panelController.refreshPanelNode.bind(e._panelController),resetBadge:e._panelController.resetBadge.bind(e._panelController),resetIndicator:function(){removeClass(e._panelController._indicatorNode,e.config.panel.indicatorClass)}}}}]),e}(),notificationClient_module_min=Main,notificationClient={NotificationClient:notificationClient_module_min},CONSUMPTION_STORAGE_KEY="lnct",NotifClient=function(){function e(){var e,n;this.personalized=!1,this.ybarElem=document.getElementById("ybar"),this.partnerClasses=null===(n=null===(e=this.ybarElem)||void 0===e?void 0:e.className)||void 0===n?void 0:n.match(/ybar-variant-([a-z]*)/),this.client=new notificationClient.NotificationClient(this.getConfig())}return e.prototype.refreshPanel=function(){var e,n,t,i=this,o={lastUpdate:this.getTimeStamp()||this.setTimeStamp(),loadInHpViewer:!0,includePersonalized:this.personalized},s=(null===(e=window.YAHOO)||void 0===e?void 0:e.context)||(null===(n=window.Af)||void 0===n?void 0:n.context)||{};return s.region&&s.lang&&(o.lang=s.lang,o.region=s.region),(null===(t=this.partnerClasses)||void 0===t?void 0:t.length)&&(o.partner=this.partnerClasses[1]),new Promise((function(e,n){i.client.helpers.refreshPanelNode({matrixParams:o},(function(t,i){t&&(logError("Notification refresh error:",t),n(t)),e(i)}))}))},e.prototype.resetBadge=function(){this.client.helpers.resetBadge(),this.setTimeStamp()},e.prototype.getConfig=function(){var e,n,t,i,o,s={promos:{eligibleBodyClass:"display-push-promos",enableNotifOnboard:!0},badge:{selector:"#notif-badge",hideClass:"ybar-notification-hidden"},panel:{emptyPanelMsg:"You have no new notifications.",errorMsg:"Please check back later.",headerMsg:"Notifications",maxCount:5,parentSelector:"#ybarNotificationBody",notificationTypes:"breakingNews"},service:{url:"/tdv2_fp/api/resource/NotificationHistory.getHistory",isRMP:!1}},r=document.getElementById("notification-container"),a=null===(e=null==r?void 0:r.dataset)||void 0===e?void 0:e.config,c={};if(a){"att"===(null===(n=this.partnerClasses)||void 0===n?void 0:n[1])&&(s.promos.showYahooLogo=!1);try{var l=JSON.parse(a);c=__assign({},l),this.personalized=1===l.personalize}catch(e){logError("Notifications config parsing error",e)}r&&delete r.dataset.config}var d=this.mergeConfigs(s,c);return(null===(t=this.partnerClasses)||void 0===t?void 0:t.length)&&"yahoo"!==(null===(i=this.partnerClasses)||void 0===i?void 0:i[1])&&(null===(o=d.promos)||void 0===o?void 0:o.subscriptionTopic)&&delete d.promos.subscriptionTopic,d},e.prototype.mergeConfigs=function(e,n){var t=__assign({},e);for(var i in e)t[i]=__assign(__assign({},e[i]),n[i]);return t},e.prototype.getTimeStamp=function(){var e;return null===(e=window.localStorage)||void 0===e?void 0:e.getItem(CONSUMPTION_STORAGE_KEY)},e.prototype.setTimeStamp=function(){var e,n=""+Math.floor((new Date).getTime()/1e3);return null===(e=window.localStorage)||void 0===e||e.setItem(CONSUMPTION_STORAGE_KEY,n),n},e}();new 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    0){if(ybarRapid.addModules(o,!1,i),beaconQueue.length>0)for(e=0;e90&&fireImageBeacon("performance",e)}catch(e){}}),1e3)}))},measureInit=measure("ybar-init");initYbar(),measureInit.stop(),initPerformanceMetricsBeaconListener(),initRapid(),initErrorBeaconListener();var selected$1="_yb_1emv3",Css$9={"right-item":"_yb_5gsz1",selected:selected$1,"ybar-mod-topnavigation":"_yb_n7tvm","ybar-mod-topnavigation-teaser-imp":"_yb_7ahee"},DOCUMENT_NODE_TYPE=9;if("undefined"!=typeof Element&&!Element.prototype.matches){var proto=Element.prototype;proto.matches=proto.matchesSelector||proto.mozMatchesSelector||proto.msMatchesSelector||proto.oMatchesSelector||proto.webkitMatchesSelector}function closest(e,n){for(;e&&e.nodeType!==DOCUMENT_NODE_TYPE;){if("function"==typeof e.matches&&e.matches(n))return e;e=e.parentNode}}var closest_1=closest;function _delegate(e,n,t,i,o){var s=listener.apply(this,arguments);return e.addEventListener(t,s,o),{destroy:function(){e.removeEventListener(t,s,o)}}}function 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0!==o&&o;if(n.ybar){n.ybar.classList.add("ybar-searchbox-assist-fullscreen"),document.documentElement.classList.add("ybar-overlay"),document.body.classList.add("ybar-overlay-noscroll");beaconClick("ybar","websrch","",{elm:"expand",subsec:"searchbox",itc:"1"}),setTimeout((function(){n.searchInput instanceof HTMLInputElement&&(t&&(n.searchInput.value=t),n.searchInput.focus(),s&&}))}},closeSearchOverlay=function(e){var n;null===(n=e.ybar)||void 0===n||n.classList.remove("ybar-searchbox-assist-fullscreen"),document.documentElement.classList.remove("ybar-overlay"),document.body.classList.remove("ybar-overlay-noscroll"),e.searchInput instanceof HTMLInputElement&&(e.searchInput.value="",e.searchInput.blur())},initMweb=function(e,n){"smartphone"===e.getConfig().device&&(e.addElementListener(n.searchBoxPlaceholder,"click",(function(){openSearchOverlay(e,n)})),e.addElementListener(n.searchBoxPlaceholder,"keydown",(function(t){var i=t,o=i.keyCode,s=i.key,r=range(65,90),a=__spreadArray(__spreadArray([],__read(range(58,57)),!1),__read(range(96,105)),!1),c=__spreadArray(__spreadArray([],__read(r),!1),__read(a),!1).includes(o);(32===o||13===o||c)&&(t.preventDefault(),t.stopPropagation(),openSearchOverlay(e,n,c?s:""))})),n.searchBoxBackButton&&(e.addElementListener(n.searchBoxBackButton,"click",(function(e){e.stopPropagation(),closeSearchOverlay(n);beaconClick("ybar","back-close-srch","",{elm:"btn",subsec:"searchbox",itc:"1"})})),e.addElementListener(n.searchInput,"keyup",(function(e){e.stopPropagation();27===e.keyCode&&(e.stopPropagation(),closeSearchOverlay(n))}))),e.addEventListener("viewerClosed",(function(){closeSearchOverlay(n)})),e.onDestroy((function(){closeSearchOverlay(n)})))},Tooltip=function(){function e(e,n,t){n&&(this.ybar=e,this.elem=n,this.options=t,,this.hide=this.hide.bind(this),this.addEventListeners())}return Object.defineProperty(e.prototype,"tooltip",{get:function(){var e=this;return this.tooltipMarkup||(this.tooltipMarkup=this.createTooltip(),(this.options.tooltipParentElm||this.elem).appendChild(this.tooltipMarkup),this.ybar.onDestroy((function(){var n,t;null===(t=null===(n=e.tooltipMarkup)||void 0===n?void 0:n.parentNode)||void 0===t||t.removeChild(e.tooltipMarkup)}))),this.tooltipMarkup},enumerable:!1,configurable:!0}),{this.tooltip.classList.add(this.options.showClass)},e.prototype.hide=function(){this.tooltip.classList.remove(this.options.showClass)},e.prototype.addEventListeners=function(){this.ybar.addElementListener(this.elem,"mouseenter",,this.ybar.addElementListener(this.elem,"focus",,this.ybar.addElementListener(this.elem,"mouseleave",this.hide),this.ybar.addElementListener(this.elem,"blur",this.hide)},e.prototype.createTooltip=function(){var e=document.createElement("div");e.className=this.options.containerClass||"";var n=document.createElement("p");return n.textContent=this.options.label,n.className=this.options.textClass||"",e.appendChild(n),e},e}();createCommonjsModule((function(module){(function(){var __webpack_modules__={"./src/index.js":/*!**********************!*\ !*** ./src/index.js ***! \**********************/function(__unused_webpack_module,__unused_webpack_exports,__webpack_require__){eval("var I18n = __webpack_require__(/*! ./lib/I18n */ \"./src/lib/I18n.js\");\n\n(function (win, doc) {\n \"use strict\";\n\n var defaultConfig = {\n uiLang: 'en-US',\n speechLang: 'en-US',\n voiceButton: '#voice-btn',\n searchBox: {\n form: '#sf',\n input: '#yschsp',\n params: {\n fr: '',\n fr2: ''\n }\n },\n enable_voice_trending: false,\n trending: {\n market: \"en-us\"\n },\n ui: {\n speechOverlay: {\n disableBlur: false\n }\n },\n browsers: {\n edge: false\n }\n };\n\n function VoiceSearch(config) {\n var self = this;\n self.config = Object.assign(defaultConfig, config || {});\n self.i18n = new VoiceSearch.I18n({\n lang: self.config.uiLang\n });\n self.renderPermissionGuide(self);\n self.renderSpeechPanel(self);\n self.speechResult = '';\n self.noSpeech = true;\n self.isRecognitionStart = false;\n self.recognition = null;\n self.voiceButton = doc.querySelector(self.config.voiceButton);\n self.searchBoxForm = doc.querySelector(self.config.searchBox.form);\n self.searchBoxQuery = doc.querySelector(self.config.searchBox.input);\n self.speechPanel = doc.querySelector('#spch');\n self.speechButtonContainer = doc.querySelector('#spchbc');\n self.speechButton = doc.querySelector('#spchbc-btn');\n self.speechText = doc.querySelector('#spcht');\n self.speechOverlay = doc.getElementById('spch-overlay');\n self.retryLink = doc.querySelector('#spcht-retry');\n self.trending = doc.getElementById('spch-trending');\n self.trendingTerms = doc.getElementById('trending-terms');\n self.termSpans = doc.getElementsByClassName(\"trending-term\");\n self.closeButton = doc.querySelector('#spchx');\n self.startAudio = new Audio('');\n self.resultAudio = new Audio('');\n self.errorAudio = new Audio('');\n self.closeAudio = new Audio('');\n self.permissionGuide = doc.querySelector('#spchp');\n self.permissionGuideClose = doc.querySelector('#spchpx');\n self.permissionGuideTimer = null;\n\n self.onEscKeyDown = function (e) {\n if (e.code !== 'Escape') {\n return;\n }\n\n self.recognition.stop();\n self.sendBeacon('keybrd', 'voicesearch_cancel_esc'); // The clean up should put inside closePanel() instead of here,\n // or func won't be cleaned up if user close panel with btn or overlay\n\n self.closePanel(self);\n };\n\n if (self.isBrowserSupported()) {\n var SpeechRecognition = win.SpeechRecognition || win.webkitSpeechRecognition;\n var SpeechGrammarList = win.SpeechGrammarList || win.webkitSpeechGrammarList;\n var speechGrammar = '#JSGF V1.0;';\n self.recognition = new SpeechRecognition();\n var speechRecognitionList = new SpeechGrammarList();\n\n if (speechRecognitionList.addFromString) {\n speechRecognitionList.addFromString(speechGrammar, 1);\n }\n\n self.recognition.grammars = speechRecognitionList;\n self.recognition.continuous = false;\n self.recognition.lang = self.config.speechLang;\n self.recognition.interimResults = false;\n self.recognition.maxAlternatives = 1;\n /* Listeners */\n\n if (self.voiceButton) {\n self.voiceButton.onclick = function () {\n self.recognition.start();\n\n if (self.permissionGuideTimer) {\n win.clearTimeout(self.permissionGuideTimer);\n }\n\n self.permissionGuideTimer = win.setTimeout(function () {\n if (!self.isRecognitionStart) {\n self.showPermissionGuide(self);\n }\n }, 300); // Also close when pressing esc\n\n doc.addEventListener('keydown', self.onEscKeyDown);\n self.sendBeacon('clk', 'voicesearch');\n };\n }\n\n if (self.speechButton) {\n self.speechButton.onclick = function () {\n if (!self.isRecognitionStart) {\n self.recognition.start();\n self.sendBeacon('clk', 'voicesearch_panel_mic_restart');\n } else {\n self.recognition.stop();\n self.sendBeacon('clk', 'voicesearch_panel_mic_close');\n self.closePanel(self);\n }\n };\n }\n\n if (self.retryLink) {\n self.retryLink.onclick = function () {\n if (!self.isRecognitionStart) {\n self.recognition.start();\n self.sendBeacon('clk', 'voicesearch_panel_retry');\n }\n };\n }\n\n if (self.speechOverlay) {\n self.speechOverlay.onclick = function () {\n self.recognition.stop();\n self.sendBeacon('clk', 'voicesearch_cancel_outside');\n self.closePanel(self);\n };\n }\n\n if (self.closeButton) {\n self.closeButton.onclick = function\n /*event*/\n () {\n self.recognition.stop();\n self.sendBeacon('clk', 'voicesearch_cancel');\n self.closePanel(self);\n };\n }\n\n if (self.permissionGuideClose) {\n self.permissionGuideClose.onclick = function\n /*event*/\n () {\n self.recognition.stop();\n self.sendBeacon('clk', 'voicesearch_permission_close');\n;\n self.hidePermissionGuide(self);\n };\n }\n /* Recognition Events */\n\n\n self.recognition.onresult = function (event) {\n // The SpeechRecognitionEvent results property returns a SpeechRecognitionResultList object\n // The SpeechRecognitionResultList object contains SpeechRecognitionResult objects.\n // It has a getter so it can be accessed like an array\n // The first [0] returns the SpeechRecognitionResult at the last position.\n // Each SpeechRecognitionResult object contains SpeechRecognitionAlternative objects that contain individual results.\n // These also have getters so they can be accessed like arrays.\n // The second [0] returns the SpeechRecognitionAlternative at position 0.\n // We then return the transcript property of the SpeechRecognitionAlternative object\n // console.log('Confidence: ' + event.results[0][0].confidence);\n self.speechResult = event.results[0][0].transcript;\n /* Punctuation Handling: Check last character and strip it if necessary */\n\n self.handlePunctuation(self);\n\n if (self.speechText) {\n self.speechText.innerText = self.speechResult;\n }\n\n if (self.searchBoxQuery) {\n self.searchBoxQuery.value = self.speechResult;\n }\n\n;\n win.setTimeout(function () {\n if (self.speechPanel) {\n self.speechPanel.classList.remove(\"s2tb\");\n self.speechPanel.classList.add(\"s2tb-h\");\n }\n\n self.hideRetryLink(self);\n\n if (self.searchBoxForm) {\n var inputFr = self.searchBoxForm.querySelector('[name=fr]');\n var inputFr2 = self.searchBoxForm.querySelector('[name=fr2]');\n\n if (inputFr && self.config.searchBox && self.config.searchBox.params && {\n inputFr.value =;\n inputFr.disabled = false; // for homepage case\n }\n\n if (inputFr2 && self.config.searchBox && self.config.searchBox.params && self.config.searchBox.params.fr2) {\n inputFr2.value = config.searchBox.params.fr2;\n inputFr2.disabled = false; // for homepage case\n }\n\n self.searchBoxForm.submit();\n }\n }, 1000);\n };\n\n self.recognition.onspeechstart = function\n /*event*/\n () {// Fired when speech starts\n };\n\n self.recognition.onspeechend = function () {\n // Fired when speech ends\n self.recognition.stop();\n };\n\n self.recognition.onerror = function\n /*event*/\n () {\n // console.log('Error occurred in recognition: ' + event.error);\n if (self.speechText) {\n self.speechText.innerText = self.i18n.t('search.voice.recognition_error');\n }\n\n self.hideTrending(self);\n self.showRetryLink(self);\n;\n };\n\n self.recognition.onaudiostart = function\n /*event*/\n () {\n // Fired when the user agent has started to capture audio.\n if (self.speechButtonContainer) {\n self.speechButtonContainer.classList.add(\"listening\");\n }\n };\n\n self.recognition.onaudioend = function\n /*event*/\n () {\n // Fired when the user agent has finished capturing audio.\n if (self.speechButtonContainer) {\n self.speechButtonContainer.classList.remove(\"listening\");\n }\n };\n\n self.recognition.onsoundstart = function\n /*event*/\n () {\n // Fired when any sound — recognisable speech or not — has been detected.\n self.hideTrending(self);\n self.noSpeech = false;\n\n if (self.speechButtonContainer) {\n self.speechButtonContainer.classList.remove(\"listening\");\n self.speechButtonContainer.classList.add(\"speaking\");\n }\n };\n\n self.recognition.onsoundend = function\n /*event*/\n () {\n // Fired when no sound present\n if (self.speechButtonContainer) {\n self.speechButtonContainer.classList.remove(\"speaking\");\n }\n };\n\n self.recognition.onstart = function\n /*event*/\n () {\n // Fired when the speech recognition service has begun listening\n self.recognitionInit(self);\n self.startRecognition(self);\n };\n\n self.recognition.onend = function\n /*event*/\n () {\n // Fired when the speech recognition service has disconnected.\n self.isRecognitionStart = false;\n\n if (self.noSpeech == false && self.speechResult == '') {\n // No match: Fired when the speech recognition can't recognise speech\n if (self.speechText) {\n self.speechText.innerText = self.i18n.t('search.voice.recognition_nomatch');\n }\n\n self.hideTrending(self);\n self.showRetryLink(self);\n;\n }\n }; // trigger onReady event when initialized\n\n\n if (document && document.dispatchEvent) {\n document.dispatchEvent(new Event('VOICE_JS_READY'));\n }\n }\n } // static members\n\n\n VoiceSearch.I18n = I18n; // instance members\n\n VoiceSearch.prototype.renderPermissionGuide = function (self) {\n var tmpl = \"\\n








    \".concat(self.i18n.t('search.voice.permission_title'), \"


    \").concat(self.i18n.t('search.voice.permission_text'), \"




    \\n \");\n var dom = new DOMParser().parseFromString(tmpl, 'text/html');\n document.body.appendChild(dom.body.children[0]);\n };\n\n VoiceSearch.prototype.renderSpeechPanel = function (self) {\n var tmpl = \"\\n


    (Video) (Part 1) Living with axial spondyloarthritis (axSpA) - Dr Barry O'Shea





    \\n \\n \\n \\n \\n \\n \\n



    \\n \\n \\n \".concat(self.i18n.t('search.voice.recognition_retry'), \"\\n






    \\n \").concat(self.i18n.t('search.voice.trending_title'), \"\\n \\n



    (Video) Diagnosing Axial Spondyloarthritis

    \\n \");\n var dom = new DOMParser().parseFromString(tmpl, 'text/html');\n\n if (self && self.config && self.config.ui && self.config.ui.speechOverlay && self.config.ui.speechOverlay.disableBlur) {\n dom.body.children[0].classList.add('disable-blur-overlay');\n }\n\n document.body.appendChild(dom.body.children[0]);\n };\n\n VoiceSearch.prototype.isBrowserSupported = function () {\n var isSupported = false;\n var self = this;\n var isChromium = Boolean(;\n var isIOSChrome = /CriOS/.test(window.navigator.userAgent);\n var isEdge = /Edg\\//.test(window.navigator.userAgent);\n var isLegacyEdge = /Edge\\//.test(window.navigator.userAgent);\n var isOpera = Boolean(window.opr);\n var isBrave = Boolean(window.navigator.brave);\n var browsers = [// chrome\n {\n checkEnabled: function checkEnabled() {\n return true;\n },\n checkBrowser: function checkBrowser() {\n return isChromium && !isIOSChrome && !isEdge && !isOpera && !isBrave;\n },\n checkAPI: function checkAPI() {\n return win && ('SpeechRecognition' in win || 'webkitSpeechRecognition' in win) && ('SpeechGrammarList' in win || 'webkitSpeechGrammarList' in win);\n }\n }, // edge\n {\n checkEnabled: function checkEnabled() {\n return self && self.config && self.config.browsers && self.config.browsers.edge;\n },\n checkBrowser: function checkBrowser() {\n return isChromium && isEdge && !isLegacyEdge;\n },\n checkAPI: function checkAPI() {\n return win && ('SpeechRecognition' in win || 'webkitSpeechRecognition' in win) && ('SpeechGrammarList' in win || 'webkitSpeechGrammarList' in win);\n }\n }];\n\n for (var b = 0; b < browsers.length; b++) {\n var browser = browsers[b];\n\n if (browser && browser.checkBrowser && browser.checkBrowser() && browser.checkEnabled && browser.checkEnabled(self) && browser.checkAPI && browser.checkAPI()) {\n isSupported = true;\n }\n }\n\n return isSupported;\n };\n\n VoiceSearch.prototype.recognitionInit = function (self) {\n // Initialize flags for checking whether user is speaking or not\n self.speechResult = '';\n self.noSpeech = true;\n self.isRecognitionStart = true;\n };\n\n VoiceSearch.prototype.showPermissionGuide = function (self) {\n if (self.permissionGuide) {\n self.permissionGuide.classList.remove(\"hide\");\n }\n };\n\n VoiceSearch.prototype.hidePermissionGuide = function (self) {\n if (self.permissionGuide) {\n self.permissionGuide.classList.add(\"hide\");\n }\n };\n\n VoiceSearch.prototype.getTrending = function (self) {\n // Call api for trending terms\n if (!self.config.enable_voice_trending || !self.trending) {\n return;\n }\n\n var url = \"\" + + \"&features=trending.voice\";\n self.ajaxReq(url, function (resBody) {\n if (!resBody || !resBody.response || ! || ! || ![\"trending.voice\"]) {\n return;\n }\n\n var terms =[\"trending.voice\"].data;\n self.showTrending(self, terms);\n });\n };\n\n VoiceSearch.prototype.showTrending = function (self, terms) {\n // params check\n if (!Array.isArray(terms) || terms.length < 3) {\n return;\n } // DOM check\n\n\n if (!self.trending || !self.termSpans || !self.termSpans[0]) {\n return;\n }\n\n var trendingLabel = '';\n trendingLabel += '\"' + terms[0].text + '\"' + ', ';\n trendingLabel += '\"' + terms[1].text + '\"' + ' ';\n trendingLabel += self.i18n.t('search.voice.trending_or') + ' ';\n trendingLabel += '\"' + terms[2].text + '\"';\n self.termSpans[0].innerText = trendingLabel;\n self.trending.classList.remove(\"hide\");\n };\n\n VoiceSearch.prototype.hideTrending = function (self) {\n if (!self.trending) {\n return;\n }\n\n self.trending.classList.add(\"hide\");\n };\n\n VoiceSearch.prototype.showRetryLink = function (self) {\n if (self.retryLink) {\n self.retryLink.innerText = self.i18n.t('search.voice.recognition_retry');\n self.retryLink.classList.remove(\"hide\");\n }\n };\n\n VoiceSearch.prototype.hideRetryLink = function (self) {\n if (self.retryLink) {\n self.retryLink.classList.add(\"hide\");\n }\n };\n\n VoiceSearch.prototype.startRecognition = function (self) {\n self.hidePermissionGuide(self);\n self.getTrending(self);\n;\n\n if (self.speechText) {\n self.speechText.innerText = self.i18n.t('search.voice.recognition_start');\n win.setTimeout(function () {\n self.speechText.innerText = self.i18n.t('search.voice.recognition_listening');\n }, 2000);\n }\n\n if (self.speechPanel) {\n self.speechPanel.classList.remove(\"s2tb-h\");\n self.speechPanel.classList.add(\"s2tb\");\n }\n\n self.hideRetryLink(self);\n };\n\n VoiceSearch.prototype.closePanel = function (self) {\n;\n win.setTimeout(function () {\n if (self.speechPanel) {\n self.speechPanel.classList.remove(\"s2tb\");\n self.speechPanel.classList.add(\"s2tb-h\");\n }\n\n self.hideTrending(self);\n self.hideRetryLink(self); // clean up esc listener\n\n doc.removeEventListener('keydown', self.onEscKeyDown);\n }, 100);\n };\n\n VoiceSearch.prototype.handlePunctuation = function (self) {\n if (self.speechResult.length > 0) {\n var lastChar = self.speechResult.charAt(self.speechResult.length - 1);\n\n if (lastChar === '.' || lastChar === '?' || lastChar === '。' || lastChar === '?') {\n self.speechResult = self.speechResult.slice(0, -1);\n }\n }\n };\n\n VoiceSearch.prototype.sendBeacon = function (actn, slk) {\n var ULT = win.YAHOO.ULT || {},\n SB = win.YAHOO.SB || {};\n\n if (ULT.beacon_click) {\n var trackParams = {\n _S: SB.config.i13n.spaceid,\n _I: SB.config.i13n.pvid,\n actn: actn,\n sec: 'search',\n slk: slk\n };\n win.YAHOO.ULT.beacon_click(trackParams);\n }\n };\n\n VoiceSearch.prototype.ajaxReq = function (url, callback) {\n var DONE_STATE = XMLHttpRequest.DONE || 4; // for IE-compatibility\n\n var xhr = new XMLHttpRequest();\n var responseRaw;\n var response; // CORS request only for IE8/IE9\n\n if (doc.documentMode && doc.documentMode < 10) {\n var xdr = new win.XDomainRequest();\n\n xdr.onload = function () {\n try {\n response = JSON.parse(responseRaw);\n callback(response);\n } catch (err) {\n return;\n }\n };\n\n'GET', url);\n xhr.send();\n return;\n } // CORS request for browers newer than IE9\n\n\n xhr.onreadystatechange = function () {\n if (xhr.readyState !== DONE_STATE) {\n return;\n } // handle ajax response\n\n\n switch (xhr.status) {\n case 200:\n responseRaw = xhr.responseText;\n\n try {\n response = JSON.parse(responseRaw);\n callback(response);\n } catch (err) {\n return;\n }\n\n break;\n\n default:\n // non-200 status code: retry or assume failure\n callback(response);\n break;\n }\n };\n\n'GET', url, true);\n /* aync request */\n\n xhr.timeout = 10000;\n xhr.send();\n };\n\n if (!win.YAHOO) {\n win.YAHOO = {};\n }\n\n if (!win.YAHOO.Util) {\n win.YAHOO.Util = {};\n }\n\n win.YAHOO.Util.VoiceSearch = VoiceSearch;\n})(window, document);\n\n//# sourceURL=webpack://@vzmi/voicejs/./src/index.js?")},"./src/lib/I18n.js":/*!*************************!*\ !*** ./src/lib/I18n.js ***! \*************************/function(module,__unused_webpack_exports,__webpack_require__){eval("module.exports = function () {\n var LANG_LIST = __webpack_require__(/*! ./lang_list.json */ \"./src/lib/lang_list.json\");\n\n var DEFAULT_LANG = 'default';\n\n var isValidLang = function isValidLang(lang) {\n return LANG_LIST.indexOf(lang) !== -1;\n }; // convert language strings to key-value map\n\n\n var buildStrMap = function buildStrMap(langStrings) {\n return langStrings.reduce(function (strMap, item) {\n strMap[] = item.defaultMessage;\n return strMap;\n }, {});\n };\n\n var I18n = function I18n(options) {\n // initialize\n this.lang = isValidLang(options && options.lang) ? options.lang : DEFAULT_LANG;\n }; // static members\n\n\n I18n.langMap = {};\n I18n.langMap[DEFAULT_LANG] = buildStrMap(__webpack_require__(/*! ../lang/strings.json */ \"./src/lang/strings.json\"));\n\n I18n.setLangMap = function (lang, strings) {\n if (lang && strings) {\n I18n.langMap[lang] = buildStrMap(strings);\n }\n }; // instance members\n\n\n I18n.prototype = {\n t: function t(id) {\n switch (true) {\n // look up target language\n case Boolean(I18n.langMap && I18n.langMap[this.lang] && I18n.langMap[this.lang][id]):\n return I18n.langMap[this.lang][id];\n // fallback to default strings\n\n case Boolean(I18n.langMap && I18n.langMap[DEFAULT_LANG] && I18n.langMap[DEFAULT_LANG][id]):\n return I18n.langMap[DEFAULT_LANG][id];\n\n default:\n return '';\n }\n }\n };\n return I18n;\n}();\n\n//# sourceURL=webpack://@vzmi/voicejs/./src/lib/I18n.js?")},"./node_modules/css-loader/dist/cjs.js!./node_modules/postcss-loader/dist/cjs.js!./src/index.css":/*!*******************************************************************************************************!*\ !*** ./node_modules/css-loader/dist/cjs.js!./node_modules/postcss-loader/dist/cjs.js!./src/index.css ***! \*******************************************************************************************************/function(module,__webpack_exports__,__webpack_require__){eval('__webpack_require__.r(__webpack_exports__);\n/* harmony import */ var _node_modules_css_loader_dist_runtime_api_js__WEBPACK_IMPORTED_MODULE_0__ = __webpack_require__(/*! ../node_modules/css-loader/dist/runtime/api.js */ "./node_modules/css-loader/dist/runtime/api.js");\n/* harmony import */ var _node_modules_css_loader_dist_runtime_api_js__WEBPACK_IMPORTED_MODULE_0___default = /*#__PURE__*/__webpack_require__.n(_node_modules_css_loader_dist_runtime_api_js__WEBPACK_IMPORTED_MODULE_0__);\n// Imports\n\nvar ___CSS_LOADER_EXPORT___ = _node_modules_css_loader_dist_runtime_api_js__WEBPACK_IMPORTED_MODULE_0___default()(function(i){return i[1]});\n// Module\n___CSS_LOADER_EXPORT___.push([, "/* Sprites */\\n#spchp.permission-guide .guide .microphone .sprite,\\n#spchp .close-button,\\n#spch .close-button,\\n#spch .spchc .microphone,\\n#spch .spchc .speaking .microphone {\\n background-image: url(;\\n background-repeat: no-repeat;\\n background-size: initial;\\n color: transparent;\\n}\\n/* Retina displays */\\n@media\\n only screen and (-webkit-min-device-pixel-ratio: 2),\\n only screen and (min-device-pixel-ratio: 2),\\n only screen and (min-resolution: 192dpi),\\n only screen and (min-resolution: 2dppx) {\\n#spchp.permission-guide .guide .microphone .sprite,\\n#spchp .close-button,\\n#spch .close-button,\\n#spch .spchc .microphone,\\n#spch .spchc .speaking .microphone {\\n background-size: 41px 330px;\\n background-image: url(\\n}\\n }\\n\\n/* permission guide */\\n#spchp.permission-guide {\\n height: 100%;\\n width: 100%;\\n padding: 0;\\n opacity: 0.9;\\n background-color: #fff;\\n left: 0;\\n overflow: hidden;\\n position: fixed;\\n text-align: left;\\n top: 0;\\n z-index: 10000;\\n transition: visibility 0s linear 0.218s, background-color 0.218s;\\n}\\n#spchp.permission-guide .close-button {\\n background-position: 0 0;\\n width: 24px;\\n height: 24px;\\n border: none;\\n cursor: pointer;\\n right: 0;\\n margin: 20px;\\n padding: 0;\\n position: absolute;\\n top: 0;\\n z-index: 10;\\n opacity: 0.8;\\n }\\n#spchp.permission-guide .close-button:hover {\\n opacity: 1;\\n }\\n#spchp.permission-guide .guide {\\n margin: 191px 0 0 507px;\\n }\\n#spchp.permission-guide .guide .microphone {\\n height: 68px;\\n width: 52px;\\n border-right: 1px solid #232a31;\\n float: left;\\n }\\n#spchp.permission-guide .guide .microphone .sprite {\\n background-position: 0 -105px;\\n width: 28px;\\n height: 28px;\\n }\\n#spchp.permission-guide .guide .guide-text {\\n height: 68px;\\n margin-left: 24px;\\n float: left;\\n }\\n#spchp.permission-guide .guide .guide-text .title {\\n color: #232a31;\\n font-size: 32px;\\n font-family: HelveticaNeue-Bold;\\n line-height: 28px;\\n margin-bottom: 16px;\\n }\\n#spchp.permission-guide .guide .guide-text .text {\\n color: #232a31;\\n font-size: 16px;\\n line-height: 28px;\\n }\\n#spchp.permission-guide.hide {\\n display: none;\\n }\\n\\n/* speech panel */\\n#spch.spch {\\n background: #fff;\\n height: 100%;\\n left: 0;\\n opacity: 0;\\n overflow: hidden;\\n position: fixed;\\n text-align: left;\\n top: 0;\\n visibility: hidden;\\n width: 100%;\\n z-index: 10000;\\n transition: visibility 0s linear 0.218s, background-color 0.218s;\\n}\\n#spch.spch .close-button {\\n background-position: 0 0;\\n width: 24px;\\n height: 24px;\\n border: none;\\n cursor: pointer;\\n right: 0;\\n margin: 20px;\\n padding: 0;\\n position: absolute;\\n top: 0;\\n z-index: 10;\\n opacity: 0.8;\\n }\\n#spch.spch .close-button:hover {\\n opacity: 1;\\n }\\n#spch.spch .spchc {\\n display: block;\\n height: 97px;\\n pointer-events: none;\\n }\\n#spch.spch .spchc .inner-container {\\n width: 100%;\\n height: 100%;\\n opacity: 0.1;\\n pointer-events: none;\\n transition: opacity 0.318s ease-in;\\n }\\n#spch.spch .spchc .inner-container .spch-control {\\n display: inline-block;\\n }\\n#spch.spch .spchc .inner-container .text-container {\\n float: left;\\n height: 91px;\\n overflow: hidden;\\n margin: 3px 0;\\n pointer-events: none;\\n width: calc(50% - 48.5px);\\n }\\n#spch.spch .spchc .inner-container .text-container p {\\n display: table-cell;\\n vertical-align: middle;\\n width: 550px;\\n height: 97px;\\n }\\n#spch.spch .spchc .inner-container .text-container .spcht {\\n font-weight: normal;\\n color: #6e7780;\\n line-height: normal;\\n opacity: 0;\\n pointer-events: none;\\n text-align: left;\\n -webkit-font-smoothing: antialiased;\\n transition: opacity 0.1s ease-in, margin-left 0.5s ease-in, top 0s linear 0.218s;\\n }\\n#spch.spch .spchc .inner-container .text-container .spcht.hide {\\n display: none;\\n }\\n#spch.spch .spchc .inner-container .text-container #spcht-retry {\\n color: #0f69ff;\\n cursor: pointer;\\n pointer-events: auto;\\n }\\n#spch.spch .spchc .inner-container .button-container {\\n pointer-events: none;\\n position: relative;\\n transition: transform 0.218s, opacity 0.218s ease-in;\\n }\\n#spch.spch .spchc .inner-container .button-container .button {\\n background-color: #fff;\\n border: 1px solid #eee;\\n border-radius: 100%;\\n bottom: 0;\\n box-shadow: 0 2px 5px rgba(0, 0, 0, 0.1);\\n cursor: pointer;\\n display: inline-block;\\n left: 0;\\n opacity: 0;\\n pointer-events: none;\\n position: absolute;\\n right: 0;\\n top: 0;\\n transition: background-color 0.218s, border 0.218s, box-shadow 0.218s;\\n }\\n#spch.spch .spchc .inner-container .button-container .button .microphone {\\n background-position: 0 -24px;\\n width: 41px;\\n height: 41px;\\n left: 27px;\\n pointer-events: none;\\n position: absolute;\\n top: 27px;\\n transform: scale(1);\\n }\\n#spch.spch .spchc .inner-container .button-container.listening .ripple {\\n position: absolute;\\n width: 136px;\\n height: 136px;\\n z-index: -1;\\n left: 50%;\\n top: 50%;\\n opacity: 0;\\n margin: -70px 0 0 -70px;\\n border-radius: 100px;\\n -webkit-animation: ripple 3.3s infinite;\\n animation: ripple 3.3s infinite;\\n background-color: #fff !important;\\n border: 2px solid #e0e4e9;\\n }\\n#spch.spch .spchc .inner-container .button-container.listening .ripple:nth-child(2) {\\n -webkit-animation-delay: 1.1s;\\n animation-delay: 1.1s;\\n }\\n#spch.spch .spchc .inner-container .button-container.listening .ripple:nth-child(3) {\\n -webkit-animation-delay: 2.2s;\\n animation-delay: 2.2s;\\n }\\n#spch.spch .spchc .inner-container .button-container.speaking .button {\\n background-color: #0f69ff;\\n }\\n#spch.spch .spchc .inner-container .button-container.speaking .button .microphone {\\n background-position: 0 -65px;\\n width: 40px;\\n height: 40px;\\n pointer-events: none;\\n position: absolute;\\n transform: scale(1);\\n }\\n#spch.spch .spchc .inner-container .button-container.speaking .ripple {\\n background-size: 114px;\\n position: absolute;\\n width: 114px;\\n height: 114px;\\n z-index: -1;\\n left: 50%;\\n top: 50%;\\n margin: -57px 0 0 -57px;\\n -webkit-animation: speakingRipple1 2s infinite;\\n animation: speakingRipple1 2s infinite;\\n }\\n#spch.spch .spchc .inner-container .button-container.speaking .ripple:nth-child(2) {\\n background-size: 123px;\\n width: 123px;\\n height: 123px;\\n margin: -62px 0 0 -62px;\\n -webkit-animation: speakingRipple2 2s infinite;\\n animation: speakingRipple2 2s infinite;\\n }\\n#spch.spch .spchc .inner-container .button-container.speaking .ripple:nth-child(3) {\\n background-size: 136px;\\n width: 136px;\\n height: 136px;\\n margin: -68px 0 0 -68px;\\n -webkit-animation: speakingRipple3 2s infinite;\\n animation: speakingRipple3 2s infinite;\\n }\\n#spch.spch .spcho {\\n background-image: linear-gradient(to bottom, rgb(255, 255, 255) 50%, rgba(255, 255, 255, 0) 99%);\\n display: block;\\n min-width: 100%;\\n text-align: center;\\n top: 145px;\\n padding-bottom: 71px;\\n pointer-events: auto;\\n }\\n#spch.spch .spcho #spch-trending {\\n -webkit-animation: fadeIn 1s forwards;\\n animation: fadeIn 1s forwards;\\n opacity: 0;\\n }\\n#spch.spch .spcho #spch-trending .trending {\\n color: #6e7780;\\n display: inline-block;\\n font-size: 16px;\\n }\\n#spch.spch .spcho #spch-trending #trending-label {\\n font-weight: bold;\\n margin: 5px 5px;\\n }\\n#spch.spch .spcho #spch-trending.hide {\\n display: none;\\n }\\n#spch.spch.s2tb .spchc, #spch.spch.s2tb-h .spchc {\\n background: #fff;\\n box-sizing: border-box;\\n box-shadow: 0 2px 6px rgba(0, 0, 0, 0.2);\\n height: auto;\\n margin: 0;\\n min-width: 100%;\\n overflow: hidden;\\n padding: 24px 115px;\\n }\\n#spch.spch.s2tb .spchc .inner-container, #spch.spch.s2tb-h .spchc .inner-container {\\n opacity: 1;\\n transition: opacity 0.318s ease-in;\\n }\\n#spch.spch.s2tb .spchc .inner-container .text-container, #spch.spch.s2tb-h .spchc .inner-container .text-container {\\n position: relative;\\n }\\n#spch.spch.s2tb {\\n background: rgba(255, 255, 255, 0);\\n opacity: 1;\\n visibility: visible;\\n transition-delay: 0s;\\n }\\n#spch.spch.s2tb .spchc .inner-container .button-container {\\n transform: scale(1);\\n height: 97px;\\n right: 0;\\n top: 0;\\n width: 97px;\\n }\\n#spch.spch.s2tb .spchc .inner-container .button-container .button {\\n opacity: 1;\\n pointer-events: auto;\\n position: absolute;\\n transform: scale(1);\\n transition-delay: 0;\\n }\\n#spch.spch.s2tb .spchc .inner-container .text-container .spcht {\\n font-size: 24px;\\n margin-left: 0;\\n opacity: 1;\\n transition: opacity 0.5s ease-out, margin-left 0.5s ease-out;\\n }\\n#spch.spch.s2tb #spch-overlay {\\n -webkit-backdrop-filter: blur(10px);\\n backdrop-filter: blur(10px);\\n background-color: #fff;\\n height: 100%;\\n opacity: 0.9;\\n position: absolute;\\n top: 149px;\\n\\n /* spchc\'s height */\\n width: 100%;\\n }\\n#spch.spch.disable-blur-overlay #spch-overlay {\\n background-color: transparent;\\n -webkit-backdrop-filter: none;\\n backdrop-filter: none;\\n }\\n#spch.spch.disable-blur-overlay .spcho {\\n height: 27px;\\n padding-bottom: 20px;\\n background: #fff;\\n background-image: none;\\n box-shadow: 0 8px 6px -6px rgb(0 0 0 / 20%);\\n }\\n#spch.spch.s2tb-h {\\n background: rgba(255, 255, 255, 0);\\n opacity: 0;\\n visibility: hidden;\\n }\\n\\n@-webkit-keyframes fadeIn {\\n 0% {\\n opacity: 0;\\n }\\n\\n 100% {\\n opacity: 1;\\n }\\n}\\n\\n@keyframes fadeIn {\\n 0% {\\n opacity: 0;\\n }\\n\\n 100% {\\n opacity: 1;\\n }\\n}\\n\\n@-webkit-keyframes ripple {\\n 0% {\\n opacity: 1;\\n transform: scale(0.7);\\n }\\n\\n 100% {\\n opacity: 0;\\n transform: scale(1);\\n }\\n}\\n\\n@keyframes ripple {\\n 0% {\\n opacity: 1;\\n transform: scale(0.7);\\n }\\n\\n 100% {\\n opacity: 0;\\n transform: scale(1);\\n }\\n}\\n\\n@-webkit-keyframes speakingRipple1 {\\n 0%,\\n 100% {\\n background-image: url(\\"\\");\\n }\\n\\n 25%,\\n 75% {\\n background-image: url(\\"\\");\\n transform: scale(1.1);\\n }\\n\\n 50% {\\n background-image: url(\\"\\");\\n transform: scale(0.9);\\n }\\n}\\n\\n@keyframes speakingRipple1 {\\n 0%,\\n 100% {\\n background-image: url(\\"\\");\\n }\\n\\n 25%,\\n 75% {\\n background-image: url(\\"\\");\\n transform: scale(1.1);\\n }\\n\\n 50% {\\n background-image: 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    Can Back Pain Be a Symptom of Axial Spondyloarthritis (AxSpA)? ›

    Osteoarthritis (OA) and axial spondyloarthritis (axSpA) can both contribute to back pain, but each may affect you differently.

    What are the symptoms of axial spondyloarthritis axSpA? ›

    Axial spondyloarthritis (axSpA)—a condition affecting the joints of the spine, chest, and pelvis—can cause back pain, fatigue, joint pain, heel pain, sleep problems, abdominal pain, and more. These symptoms often occur after periods of inactivity, like sleeping or resting.

    What does ankylosing spondylitis back pain feel like? ›

    People with Ankylosing Spondylitis often describe an ongoing, dull pain that feels like it's coming from deep within their lower back or buttocks, along with morning stiffness. It is not unusual for symptoms to worsen, get better or stop completely at regular intervals.

    Does ankylosing spondylitis cause back pain? ›

    The most common symptom of ankylosing spondylitis is lower back and/or hip pain and stiffness. Over time, the symptoms may progress to other areas of the spine.

    What does axSpA feel like? ›

    Symptoms of axSpA include: Pain in the low back, buttocks and hips that develops slowly over weeks or months. Pain, swelling, redness and warmth in the toes, heels, ankles, knees, rib cage, upper spine, shoulders and neck. Stiffness when first waking up or after long periods of rest.

    What triggers axial spondyloarthritis? ›

    The exact cause of axial spondyloarthritis is not clear. Researchers believe that people with certain genes develop axial spondyloarthritis when they are exposed to a certain virus, bacteria or other environmental trigger. More than 9 out of 10 people with axial spondyloarthritis have a gene called HLA-B27.

    What does a spondyloarthritis flare feel like? ›

    According to these studies, a typical AS flare is characterized by increased back pain that may be stabbing in nature or feel like muscle cramps. Symptoms can be local or more generalized. Increased fatigue and emotional upset are common. Episodes may last from a few days to a few weeks.

    What are the 3 most common symptoms of ankylosing spondylitis? ›

    Early symptoms of ankylosing spondylitis might include back pain and stiffness in the lower back and hips, especially in the morning and after periods of inactivity. Neck pain and fatigue also are common. Over time, symptoms might worsen, improve or stop at irregular intervals.

    What helps back pain from ankylosing spondylitis? ›

    1. Physiotherapy and exercise. Keeping active can improve your posture and range of spinal movement, along with preventing your spine becoming stiff and painful. ...
    2. Painkillers. ...
    3. Biological treatments. ...
    4. JAK inhibitors. ...
    5. Corticosteroids. ...
    6. Disease-modifying anti-rheumatic drugs (DMARDs) ...
    7. Surgery. ...
    8. Follow-up.

    What are the red flags of ankylosing spondylitis? ›

    Chronic pain and stiffness in the lower back where your spine meets your pelvis. Ankylosing spondylitis causes chronic pain that can come and go. You might experience periods of flares and stiffness, and other times when you don't feel pain as acutely.

    Where is ankylosing spondylitis back pain? ›

    Ankylosing spondylitis (AS) is a rare type of arthritis that causes pain and stiffness in your spine. This lifelong condition, also known as Bechterew disease, usually starts in your lower back. It can spread up to your neck or damage joints in other parts of your body.

    What are the 4 body areas affected by ankylosing spondylitis? ›

    Ankylosing spondylitis may affect more than the spine. The disease may inflame joints in the pelvis, shoulders, hips and knees, and between the spine and ribs.

    What is a major flare of ankylosing spondylitis? ›

    What are the symptoms of an ankylosing spondylitis (AS) flare-up, and how can a person treat them? Symptoms of an AS flare-up can include fatigue, back stiffness, fever, depression, and joint pain. To treat an AS flare-up, a person can try medication, gentle exercise, and heat or cold therapy.

    What is the average age of onset for axSpA? ›

    Axial SpA (AS) is a condition that affects young people. Symptoms start late teens to early twenties, with the average age of onset being 24.

    What is the first line treatment for axSpA? ›

    NSAIDs for management of symptoms and inflammation in axSpA

    NSAIDs remain the first-line drug treatment, in those without contra-indications, for symptoms in axSpA [1,2].

    How do you test for axSpA? ›

    Imaging Tests
    • X-ray. X-rays of the spine and pelvis showing characteristic bone damage can be useful in diagnosing radiographic axSpA, known as ankylosing spondylitis. ...
    • Ultrasound. ...
    • Magnetic resonance imaging (MRI). ...
    • Computed Tomography (CT) Scan.

    Does axial spondyloarthritis show up on MRI? ›

    MRI of the sacroiliac joints (SIJs) is recognised as key imaging biomarker of axial spondyloarthritis (SpA), especially for recognition of emerging inflammation in the early phase of the disease.

    Where is the pain with axial spondyloarthritis? ›

    The most common symptom of axial spondyloarthritis (axSpA) is pain in the lower back. Some people also have pain, stiffness, and limited mobility outside the spine, such as in the hips, knees, and heels.

    What medication is used for spondyloarthritis? ›

    Spondyloarthritis Treatment

    Nonsteroidal anti-inflammatory drugs. NSAIDs like ibuprofen, indomethacin (Tivorbex), meloxicam (Mobic), and naproxen (Aleve, Anaprox, Naprosin) can help with your symptoms. Corticosteroid medication. Shots in your joints or in the membrane around your tendon can work quickly.

    How long do axial spondyloarthritis flares last? ›

    People with AS tend to have chronic lower back, pelvic, and hip pain that comes and goes; during a flare, it can feel significantly more intense and debilitating. Research indicates that flares in AS are very common. One study found that AS patients had about one flare a month; each flare lasted about two weeks.

    Is walking good for spondyloarthritis? ›

    Walk It Off

    For those who can safely exercise, Dr. Tehrani recommends low-impact activities like walking. Joint deformities, fused joints, misinformation, and fear of getting hurt can discourage some people from exercising, Tehrani says, but walking is a great way to ease into physical activity.

    Does ankylosing spondylitis hurt all day long when flaring? ›

    An ankylosing spondylitis flare-up may cause chronic back pain over time. You may feel dull to burning pain on both sides of the lower back, buttocks, and hips. Chronic pain can last for 3 months or longer.

    What autoimmune disease causes back pain? ›

    Ankylosing spondylitis (AS) is a type of inflammatory arthritis that mainly affects the spine. Symptoms of AS include back pain, stiffness and reduced mobility in the spine. Ankylosing spondylitis commonly affects the sacroiliac joints. These joints connect the base of the spine (sacrum) to your pelvis.

    Why does my lower back hurt all of a sudden? ›

    Acute low back pain is most often caused by a sudden injury to the muscles and ligaments supporting the back. The pain may be caused by muscle spasms or a strain or tear in the muscles and ligaments. Causes of sudden low back pain include: Compression fractures to the spine from osteoporosis.

    What illness mimics ankylosing spondylitis? ›

    Enteropathic Arthritis

    It involves joints in your arms and legs, most often your lower legs. It can also cause inflammation in your lower spine and sacroiliac joints or affect your entire spine — similar to AS.

    What muscle relaxant is good for spondylitis? ›

    Methocarbamol (Robaxin) Skeletal muscle relaxant used in conjunction with other therapies to treat pain and discomfort associated with musculoskeletal conditions. Reduces nerve impulse transmission from spinal cord to skeletal muscle.

    What is the new drug for ankylosing spondylitis? ›

    U.S. FDA Approves Pfizer's XELJANZ® (tofacitinib) for the Treatment of Active Ankylosing Spondylitis.

    Do muscle relaxers help ankylosing spondylitis? ›

    Spasms in spinal muscles in ankylosing spondylitis patients cause pain and limitation of motion. The addition of a muscle relaxant to an NSAID helps decrease muscle pain and tightness.

    Can a blood test detect ankylosing spondylitis? ›

    At this time, no single test diagnoses ankylosing spondylitis. Your doctor may order a blood test to check for the HLA-B27 gene, which is present in most people with the disease. You may have the HLA-B27 gene and never develop ankylosing spondylitis, but it can give doctors more information when making a diagnosis.

    Does ankylosing spondylitis always show on MRI? ›

    It's important to remember that an MRI cannot rule out ankylosing spondylitis completely. It's possible to have AS and a seemingly regular MRI, especially early on in the disease.

    What is the last stage of ankylosing spondylitis? ›

    Advanced Ankylosing Spondylitis

    If you have more advanced AS, your doctor may tell you that your spine has fused. That happens when new bone grows between some of the small bones that form your spine, joining them together. The more this happens, the less movement you have in your spine.

    Is ankylosing spondylitis the same AS axial spondyloarthritis? ›

    Ankylosing spondylitis is the more severe subtype of axial spondyloarthritis (axSpA). It means the damage to your joints is visible on an X-ray. But some experts think this distinction isn't clinically significant and consider axSpA as more of a spectrum.

    What part of the body is most commonly affected by ankylosing spondylitis? ›

    Ankylosing spondylitis (AS) (ank-ee-lo-zing spon-dee-li-tus) is a type of arthritis that mainly affects the back, by causing inflammation in the spine. This can make your back, rib cage and neck stiff and painful. It often starts in people who are in their late teens or 20s.

    Does ankylosing spondylitis feel like sciatica? ›

    The type of pain you feel is likely a clue as to what condition you're dealing with. Ankylosing spondylitis pain tends to be duller and makes you feel stiff around the lower back and hips. Pain from sciatica is often a sharp, shooting pain that radiates down one side of your buttocks and leg.

    What is strongly associated with ankylosing spondylitis? ›

    The first human leukocyte antigen (HLA) haplotype association with human inflammatory disease was discovered in 1972, correlating HLA-B27 with ankylosing spondylitis. This remains one of the strongest known associations of this disease with HLA-B27.

    What is stage 2 of ankylosing spondylitis? ›

    In the second stage, joint involvement, particularly in the sacroiliac joints (located between the pelvis and spine), is visible on x-rays. Along with the symptoms of AS, these features make AS more likely to be diagnosed at this stage. In the third stage, joint damage has occurred and is irreversible.

    What bacteria causes ankylosing spondylitis? ›

    Ankylosing spondylitis is caused by Klebsiella.

    Will I end up in a wheelchair with ankylosing spondylitis? ›

    It is a rare disease, there is no cure, and you will end up in a wheelchair.

    How is ankylosing spondylitis triggered? ›

    Ankylosing spondylitis is a chronic, inflammatory disorder and a rare form of arthritis. Triggers for ankylosing spondylitis include infections (gastrointestinal infections, urinary tract infections [UTIs], and respiratory infections), heavy physical activity, work stress, emotional stress, and pregnancy.

    How debilitating is ankylosing spondylitis? ›

    In some cases, ankylosing spondylitis can be debilitating and lead to disability, according to the SAA. Over time, the inflammation associated with ankylosing spondylitis can cause the vertebrae of the spine to fuse together. In severe cases, when this happens, the spine can curve and cause a stooped position.

    Does stress make spondyloarthritis worse? ›

    That's because stress can exacerbate ankylosing spondylitis symptoms, including pain, according to the Spondylitis Association of America. Stress may also trigger an ankylosing spondylitis flare, a period of increased inflammation and worsening symptoms.

    What happens if you don't treat spondyloarthritis? ›

    You might end up with a deformed spine

    As the disease progresses, moving your spine gets increasingly difficult. The less you move your spine, the stiffer it can get. In the most severe cases, chronic inflammation causes the formation of extra bone between your vertebrae.

    How rare is axial spondyloarthritis? ›

    Abstract. Axial spondyloarthritis (axSpA) is an important cause of chronic low back pain and affects approximately 1% of the US population. The back pain associated with axSpA has a characteristic pattern referred to as inflammatory back pain (IBP).

    How do you sleep with axial spondyloarthritis? ›

    Sleep on your back to ease ankylosing spondylitis symptoms

    Many people find relief from their ankylosing spondylitis symptoms by sleeping on their back. I tell my patients that the key to sleeping in this position is to maintain the natural curvature of their spine.

    Is axial spondyloarthritis painful? ›

    Axial Spondyloarthritis - also known as axSpA or axial SpA - is a painful, chronic arthritis that mainly affects the joints of the spine.

    What does axial spondyloarthritis pain feel like? ›

    Signs and Symptoms of Axial Spondyloarthritis. The primary symptom of axSpA is inflammatory back pain, which is back pain that occurs because of chronic inflammation in the joints of your spine.

    Does spondyloarthritis show up in blood tests? ›

    There are no specific lab tests to identify ankylosing spondylitis. Certain blood tests can check for markers of inflammation, but many different health problems can cause inflammation. Blood can be tested for the HLA-B27 gene.

    What are the clinical features of axSpA? ›

    A, Spondyloarthritis features include alternating buttock pain, dactylitis, asymmetrical arthritis, elevated acute-phase reactants (e.g., CRP or erythrocyte sedimentation rate), enthesitis, inflammatory back pain, inflammatory bowel disease, family history of SpA in a first- or second-degree relative, marked response ...

    How do you diagnose axSpA? ›

    Healthcare providers diagnose axSpA if you have back pain and other symptoms of axSpA, even if an imaging test doesn't show inflammation. If you have symptoms of axSpA but no visible inflammation in the spine, your provider may diagnose non-radiographic axSpA.

    How do you treat axSpA? ›

    Treatment for axSpA usually starts with nonsteroidal anti-inflammatory drugs (NSAIDs), physical therapy and exercise. As long as your disease isn't too advanced, NSAIDs and regular movement are usually enough to keep things under control.

    What is the criteria for axSpA? ›

    According to the ASAS classification criteria, patients who experience chronic back pain before the age of 45 years have axSpA if they (1) have imaging evidence of sacroiliitis (by MRI or radiography) plus 1 or more spondyloarthritis (SpA) feature or (2) are positive for human leukocyte antigen B27 (HLA-B27) and have 2 ...

    What is axial spondyloarthritis inflammatory back pain? ›

    Axial spondyloarthritis (axial SpA) is an inflammatory arthritis where the main symptom is back pain. Where changes to the sacroiliac joints or the spine can be seen on x-ray. Where x-ray changes are not present but inflammation is visible on MRI or you have symptoms.

    How does spondyloarthritis affect the spine? ›

    Ankylosing spondylitis, also known as axial spondyloarthritis, is an inflammatory disease that, over time, can cause some of the bones in the spine, called vertebrae, to fuse. This fusing makes the spine less flexible and can result in a hunched posture. If ribs are affected, it can be difficult to breathe deeply.

    What blood test shows axial spondyloarthritis? ›

    HLA-B27 test.

    HLA-B27 is a specific HLA associated with axSpA and related diseases. While not all people with axSpA test positive for HLA-B27, approximately 90% do, making it an important diagnostic tool for someone with axSpA symptoms.

    What is the drug of choice for spondyloarthritis? ›

    Nonsteroidal anti-inflammatory drugs (NSAIDs) — such as naproxen sodium (Aleve) and ibuprofen (Advil, Motrin IB, others) — are the medicines health care providers most commonly use to treat axial spondyloarthritis and nonradiographic axial spondyloarthritis.

    What medications are used for axSpA? ›

    Several biologics and their biosimilars are currently approved for use in AS: adalimumab (Humira), certolizumab pegol (Cimzia), etanercept (Enbrel), golimumab (Simponi), infliximab (Remicade), ixekizumab (Taltz) and secukinumab (Cosentyx).

    What are risk factors for axSpA? ›

    While researchers haven't discovered a definitive cause of axSpA, they have identified unmodifiable risk factors that may contribute to its development. These include genetics and the presence of conditions such as inflammatory bowel diseases and osteoporosis, sex, and age.

    Does spondyloarthritis show on MRI? ›

    Spondyloarthritis has two hallmark features: active inflammation and structural lesions with new bone formation. MRI is well suited to assess active inflammation, but there is increasing interest in the role of structural lesions at MRI.

    Is axSpA hereditary? ›

    Some genes may increase the risk that a person will develop axSpA. A person is more likely to develop axSpA if a family member has one of these genes or genetic markers. People who have a genetic marker called HLA-B27 are at a higher risk of developing axSpA.


    (Monster Pain in the AS)
    2. Recognizing Axial Spondyloarthritis
    (Mayo Proceedings)
    3. The Diagnosis and Management of Axial Spondyloarthritis
    (Musculoskeletal Australia)
    4. "My chronic back pain is Axy What?" Axial Spondyloarthritis and Ankylosing Spondylitis
    (National Centre for Sport and Exercise Medicine)
    (Monster Pain in the AS)
    6. Can you say axial spondyloarthritis?
    (National Axial Spondyloarthritis Society)


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